Lu et al. show that MLL-rearranged leukemia is addicted to the transcription factor ZFP64 due to direct regulation of MLL by ZFP64. The MLL promoter has an unusually high number of ZFP64 binding motifs and is the most enriched location of ZFP64 occupancy in the human genome.
from Cancer Cell https://ift.tt/2rd2dMt
from Cancer Cell https://ift.tt/2rd2dMt