Signaling downstream of RAS is subject to many levels of regulation. Inhibiting MEK seems to re-wire that regulation so that inhibitors of RAF kinases are more effective against cells driven by mutant KRAS.
from RAS Dialogue https://ift.tt/2rxqHk1
Signaling downstream of RAS is subject to many levels of regulation. Inhibiting MEK seems to re-wire that regulation so that inhibitors of RAF kinases are more effective against cells driven by mutant KRAS.