Targeting the Vulnerability of Glutathione Metabolism in ARID1A-Deficient Cancers

Ogiwara et al. show that ARID1A-deficient cancer cells express low levels of the key cystine transporter SLC7A11 and thus have low basal levels of glutathione (GSH), which make these cancer cells specifically vulnerable to inhibition of the GSH metabolic pathway.

from Cancer Cell http://bit.ly/2B3OFZ0