Mutational Signature Analysis Reveals NTHL1 Deficiency to Cause a Multi-tumor Phenotype

In addition to the know colorectal tumors, Grolleman et al. find tumors in 13 tissue types, including a high breast cancer incidence, among 29 carriers of biallelic germline NTHL1 mutations and identify a mutation signature across tumor types, which may facilitate the identification and management of new cases.

from Cancer Cell http://bit.ly/2tfuxip