Inhibition of MAPK Signaling Increases Autophagy in Mutant RAS Cancers

Cancers driven by mutant RAS genes show increased autophagy. Unexpectedly, inhibition of signaling through mutant RAS further increases autophagy. Dual inhibition of MAPK signaling and autophagy inhibits pancreatic cancer.

from RAS Dialogue https://ift.tt/2OtCydw