Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties

Kong et al. show that histone and hemimethylated DNA reader domains are critical for UHRF1 to maintain aberrant DNA methylation in colorectal cancer (CRC) cells. Blocking either domain reverses DNA hypermethylation, reactivates epigenetically silenced tumor suppressor genes, and reduces CRC oncogenic properties.

from Cancer Cell https://ift.tt/2UiZan9