Somatic hotspot mutations found in tumors are generally considered evidence for selection and are used to nominate tumor drivers. Hess et al. show that many hotspots occur at inherently mutable sites without selection and develop a model that accounts for these passenger hotspots, which can more accurately nominate true driver mutations.
from Cancer Cell https://ift.tt/30pGQXw
from Cancer Cell https://ift.tt/30pGQXw