Etxeberria et al. engineer tumor-specific CD8+ T cells that transiently express IL-12 to mitigate toxicity and show that intratumoral injection of these engineered T cells in conjunction with local CD137 co-stimulation leads to epitope spreading and regression of injected and distant lesions in solid tumor models.
from Cancer Cell https://ift.tt/2pD60pd
from Cancer Cell https://ift.tt/2pD60pd