Zheng et al. find that the Ras-GAP NF1 is also a transcriptional co-repressor of estrogen receptor α (ER). NF1 loss leads to estradiol hypersensitivity and tamoxifen agonism. A selective ER degrader and MEK inhibitor combination induces tumor regression in mouse models of NF1-deficient ER+ breast cancer.
from Cancer Cell https://ift.tt/2PPMzUh
from Cancer Cell https://ift.tt/2PPMzUh