Dheilly et al. find cathepsin S (CTSS) overexpression and a recurrent activating CTSS mutation in follicular lymphoma patients. Modifying CTSS activity and expression in mouse models affects antigen processing, crosstalk between T cells and malignant B cells in the tumor microenvironment, and lymphomagenesis.
from Cancer Cell https://ift.tt/2XXXiAI
from Cancer Cell https://ift.tt/2XXXiAI