PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression

Yotaro et al. define a tumor suppressor role for PKCλ/ι in hepatocellular carcinoma (HCC). PKCλ/ι loss induces oxidative phosphorylation, reactive oxygen species production, and autophagy. These events activate an NRF2 transcriptional program that supports HCC progression.

from Cancer Cell https://ift.tt/2BcF71h