Siersbæk et al. show that IL6/STAT3 signaling is functionally decoupled from ER in breast cancer. IL6-activated STAT3 promotes metastasis by co-opting a subset of shared ER-FOXA1-STAT3 enhancers to drive a distinct transcriptional program independent of ER and FOXA1. This suggests a clinical potential for targeting IL6/STAT3 in ER+ breast cancer.
from Cancer Cell https://ift.tt/2ChAgMN
from Cancer Cell https://ift.tt/2ChAgMN