Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors

Han et al. show that CXorf67 interacts with PALB2 and obstructs the PALB2-BRCA2 interaction, thereby inhibiting homologous recombination repair. A combination of PARP inhibitors with radiotherapy could be an effective treatment option for PFA ependymomas with elevated CXorf67 expression.

from Cancer Cell https://ift.tt/32CbNM9