Analyzing integrative enhancer profiles and transcription factor dependencies, Ott et al. construct enhancer-based core regulatory circuits of chronic lymphocytic leukemia (CLL) and reveal a dominant and essential role for PAX5. BET inhibition disrupts CLL super enhancer networks and suppresses CLL growth.
from Cancer Cell https://ift.tt/2FO0aJ4
from Cancer Cell https://ift.tt/2FO0aJ4