DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns

Skvortsova et al. identify promoter CpG islands that display partial methylation encroachment across one or both borders, which is often associated with gene suppression, and show that the pattern of H3K4me1 at CpG island borders in normal cells predicts patterns of cancer CpG island hypermethylation.

from Cancer Cell http://bit.ly/2timAZW
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