Protein Kinase Cι and Wnt/β-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma

Yin et al. discover that KrasG12D;Trp53−/− (KP)-driven mouse lung adenocarcinomas (LADCs) are phenotypically different from KP LADCs without PKCι (KPI) expression. A KPI-derived genomic signature identifies KPI-like human LADCs and predicts susceptibility to Wnt inhibitors.

from Cancer Cell https://ift.tt/2YDUfu4