Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention

O'Connor et al. show that lymphoma cells (LCs) enter the brain but quickly exit along an endothelial CXCL12 gradient, which is countered by astrocyte-derived CCL19. Aged and gliotic brains express more CCL19 and thus retain LCs longer, conferring an increased risk of developing central nervous system lymphoma.

from Cancer Cell https://ift.tt/2IbdG8f