Bai et al. develop SD-36, a proteolysis targeting chimera (PROTAC) that selectively degrades STAT3 and inhibits the growth of leukemia and lymphoma cell lines. SD-36 is well tolerated in immune-competent mice and induces durable tumor regression in vivo in xenograft models.
from Cancer Cell https://ift.tt/2pd2NwA
from Cancer Cell https://ift.tt/2pd2NwA