Luo et al. find that the lncRNA HOTTIP is overexpressed in acute myeloid leukemia (AML). They show that HOTTIP coordinates topologically associated domain organization in the AML genome, including the posterior HOXA genes and various key hematopoietic regulator loci, and is important for AML growth.
from Cancer Cell https://ift.tt/2sn0Dvv
from Cancer Cell https://ift.tt/2sn0Dvv