THEMIS-SHP1 Recruitment by 4-1BB Tunes LCK-Mediated Priming of Chimeric Antigen Receptor-Redirected T Cells

Sun et al. uncover the mechanisms by which CD28 and 4-1BB differentially regulate the equilibrium of phosphorylation and dephosphorylation of CAR-CD3ζ to affect the magnitude of CAR-T cell activation. LCK kinase and SHP1 phosphatase can be engineered in CAR-T cells to tune their activity.

from Cancer Cell https://ift.tt/36AO269