Ireland et al. show that MYC activates Notch signaling to dedifferentiate neuroendocrine small cell lung cancer (SCLC) in a conserved trajectory from ASCL1+ to NEUROD1+ to YAP1+ non-neuroendocrine subtypes, suggesting that these are not distinct subtypes but different stages of progressive evolution of SCLC.
from Cancer Cell https://ift.tt/2TRek0u
from Cancer Cell https://ift.tt/2TRek0u