Su et al. develop two potent small-molecule inhibitors against an RNA N6-methyladenosine demethylase called FTO. FTO inhibition shows anti-tumor effects in several types of cancers in mouse models by restricting self-renewal of cancer stem cells and suppressing immune evasion.
from Cancer Cell https://ift.tt/30JnVej
from Cancer Cell https://ift.tt/30JnVej