Salik et al. identify a positive modulator of canonical WNT signaling pathway that drives the self-renewal of leukemia stem cells in a subset of acute myeloid leukemia (AML). An antibody blocking the ligand and receptor interaction of this pathway could be a potential therapeutic to treat aggressive AML.
from Cancer Cell https://ift.tt/3hIHTvt
from Cancer Cell https://ift.tt/3hIHTvt