Mender et al. show that cancer cells treated with the nucleoside analog 6-thio-2′-deoxyguanosine (6-thio-dG) undergo telomere stress and release DNA that is sensed by dendritic cells via STING-interferon signaling, which in turn activates CD8+ T cells. 6-thio-dG synergizes with immune checkpoint inhibitors.
from Cancer Cell https://ift.tt/2YQilVT
from Cancer Cell https://ift.tt/2YQilVT