Zhang et al. find that cancer-associated fibroblasts promote antiandrogen resistance in prostate cancer by secreting NRG1 to activate HER3 signaling in prostate cancer cells. Blockade of the NRG1/HER3 axis can re-sensitize prostate cancer models to antiandrogen therapy.
from Cancer Cell https://ift.tt/3j6AwPg
from Cancer Cell https://ift.tt/3j6AwPg