Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer

Gabitova-Cornell et al. show that disruption of cholesterol biosynthesis by Nsdhl knockout or treatment with statins switches glandular pancreatic carcinomas to a basal subtype via activation of SREBP1, which induces Tgfb1 expression, autocrine TGF-β-SMAD2/3 signaling, and epithelial-mesenchymal transition.

from Cancer Cell https://ift.tt/32Wg4L0