Chen and Liang provide a high-resolution map of eRNA loci through which super-enhancer activities can be conveniently quantified by RNA-seq. The eRNA signals in cancer samples are clinically relevant and provide additional explanatory power for cancer phenotypes beyond those provided by mRNAs through resolving intra-tumor heterogeneity with enhancer cell-type specificity.
from Cancer Cell https://ift.tt/3ieRhWQ
from Cancer Cell https://ift.tt/3ieRhWQ