Dammeijer et al. show that PD-1/PD-L1 interactions occur frequently in tumor-draining lymph nodes (TDLNs) and that specific targeting of PD-L1 in the TDLN induces an effective anti-tumor immune response in multiple mouse models. In addition, PD-1/PD-L1 interactions in TDLNs, but not in tumor, correlate with prognosis in melanoma patients.
from Cancer Cell https://ift.tt/36omgxe
from Cancer Cell https://ift.tt/36omgxe