Guccini et al. show that TIMP1 loss switches senescence from a tumor-suppressive to a pro-metastatic process in prostate cancer mouse models. Pharmacological targeting of TIMP1-deficient senescent tumor cells impedes metastases i…
Han et al. show that CXorf67 interacts with PALB2 and obstructs the PALB2-BRCA2 interaction, thereby inhibiting homologous recombination repair. A combination of PARP inhibitors with radiotherapy could be an effective treatment o…
Gene expression analyses have identified subtypes of conventional renal cell carcinoma broadly distributed into angiogenic and proliferative/ immunogenic clades. Integration with genomic and functional experiments in animal model…
Motzer et al. perform integrative multi-omics analyses of 823 renal cancer tumors from a randomized clinical trial. A robust molecular classification scheme, based on transcriptional and gene alteration profiles and differential …
Zhao et al. profile the protein responses of a large collection of cancer cell lines to drug perturbations using the RPPA platform and build a systematic protein-drug connectivity map. The integration of perturbed protein respons…
Chang et al. report that YTHDF3 overexpression associates with breast cancer brain metastasis and confers poor survival. Mechanistically, YTHDF3 enhances the expression of m6A-enriched transcripts that promote cancer cell-brain m…
Tumor mutational burden (TMB) reflects cancer mutation quantity. Mutations are processed to neo-antigens and presented by major histocompatibility complex (MHC) proteins to T cells. To evade immune eradication, cancers exploit ch…
Immune cells' metabolism influences their differentiation and function. Given that a complex interplay of environmental factors within the tumor microenvironment (TME) can have a profound impact on the metabolic activities of…
When the COVID-19 pandemic began, formal frameworks to collect data about affected patients were lacking. The COVID-19 and Cancer Consortium (CCC19) was formed to collect granular data on patients with cancer and COVID-19 at scal…
Deep neural networks often achieve high predictive accuracy on biological problems, but it can be hard to contextualize how and explain why predictions are made. In this issue, Kuenzi et al. model the sensitivity of cancers to dr…
Zhou et al. provide evidence for the prevalence of somatic copy number alterations in fibroblasts, immune cells, and endothelial cells in both colorectal cancer and normal tissues. The proportions of aneuploid fibroblasts in tumo…
Kuenzi et al. develop DrugCell, an interpretable deep learning model that simulates the response of human cancer cells to therapy. DrugCell predictions might generalize to patient tumors and can be used to design synergistic drug…
CD19-specific CAR-T cell therapies are the gold standard of adoptive cellular immunotherapy for hematopoietic malignancies. In Science Translational Medicine, Park et al. develop an oncolytic vaccinia virus that introduces trunca…
Countries in Latin America and the Caribbean have become hotspots of the novel coronavirus (COVID-19) pandemic, exacerbating socioeconomic inequalities and overwhelming fragmented health systems. Studies from the United States an…
Coronavirus disease 2019 (COVID-19), like cancer, is a complex disease with clinical phases of progression. Initially conceptualized as a respiratory disease, COVID-19 is increasingly recognized as a multi-organ and heterogeneous…
Beginning November 2, 2020, opening clinical notes to patients with cancer will no longer be a decision left to individual clinicians or institutional preference but rather a requirement, as a result of the 21st Century Cures Act…
To understand the real impact of COVID-19 on cancer patients, an entirely new data collection effort was initiated within the Thoracic Cancers International COVID-19 Collaboration (TERAVOLT). TERAVOLT reported high mortality rela…
